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Maclin is a carrier MDR1 what that means is he carries 1 copy of the gene. When choosing a female for Maclin she needs to be clear of MDR1 so some puppies will be carriers like Maclin and some will be clear like the mother. MDR1 is like an allergy to Ivermectin products. There are plenty of medications on the market that do not contain Ivermectin to dogs that are carriers or have 2 copies of the gene. Most veterinarians will treat all Australian Shepherds and other herding breeds with medications not containing Ivermectin as a precaution because their are breeders that do not test their dogs.